For some time now, the "traditional" option has been soft gels. The main advantage of soft capsules is that they are formed, filled, and sealed in one operation. Tamper-resistant; easy to swallow; and available in a variety of shapes, sizes, and colors.

    That said, there are many reasons why two-piece hard capsules should be considered a liquid-filled option, and may often be the better option.

    What is the reason for the popularity of LFHC?

    Less Infrastructure: One of the greatest advantages of LFHC is that manufacturing does not require a large investment in expensive gelatin preparation equipment, and has a correspondingly large facility footprint, which is required for soft capsules. LFHC manufacturing also eliminates the need to retain raw materials for this gelatin formulation. With LFHC, capsules are pre-manufactured and can be filled using off-the-shelf and easy-to-use filling equipment. By contrast, the capital equipment requirements for soft gels result in the need to use a specialized third-party manufacturer and incorporate the associated cost and timeline issues into your plan.

    Faster manufacturing: While soft gels take three to four days from gelatin preparation to blister packaging, all steps in the LFHC process cycle are completed within one day, including capsule bundling or sealing.

    Less complex manufacturing: Softgel manufacturing is done by only a limited number of facilities; LFHC manufacturing is usually done in-house. Compared to soft gel manufacturing equipment, equipment to produce LFHC is cheaper and takes up less space; uses less than one-third of the electricity; requires less expertise to operate, and can be run with fewer people. The simpler process of LFHC also makes this dosage form easier to expand.

    Less stringent manufacturing conditions: For the manufacture of soft gels, the relative humidity at room temperature must be maintained between 20% and 30%. Compare this too hard capsule filling, which can be performed at room temperature up to 60% relative humidity.

    No wasted gelatin material: Softgel manufacturing results in wasted gelatin up to 40% of the web size. Gelatin-based hard capsules do not waste gelatin.

    Options for filling with nitrogen atmosphere: As with soft gels, inert gases such as nitrogen can be used to add an additional protective layer to the filling material when manufacturing LFHC.

    Xinchang Hexin Capsules Co., Ltd. is a China-based Empty Gelatin Capsules Supplier and Empty HPMC Capsules Wholesaler, with Empty HPMC Capsules, Empty Gelatin Capsules for sale.